Batch calorimeters are useful tools for quickly estimating the yield of reactions under different conditions such as solvent type, pH, ionic strength, etc. Calorimeters do not require any special sample preparation such as extractions, dilutions, filtration etc. to quantify the reaction progress (which is not the case for other methods such as spectroscopy or HPLC). In the example shown here the extent of degradation of an ester by base, which is proportional to the total heat output, was shown to be strongly dependent on the relative amount of organic solvent used.
|Kinetics of the reaction can be determined by plotting the fractional heat versus time. The t1/2 can be read directly from the plot and used to calculate an apparent first order rate constant. The data shows that the rate of the reaction was also strongly dependent on solvent composition.|