In water the whole tablet
dissolved in about 100 seconds with a Cmax of about 15 seconds.
the enteric coating was found to dissolve in pure antacid media. The bulk
tablet disintegrated, but did not dissolve. These
results correlated with an observed decrease in in vivo bioavailability when
subjects used OTC antacid.
thermal method does not require any sample filtration and can be
performed without development of a UV or HPLC method.
makes it a powerful screening and QC tool for dissolution
testing of pharmaceuticals, dyes, pigments, photoresists, etc., especially in the
preformulation stages of product development.